Acute medical management of bradycardia attributable to SND or atrioventricular block

 in case if symptomatic sinus bradycardia or atrioventricular block 

atropine : 0.5-1mg iv (may repeated every 3-5min to maximum dose of 3mg )

dopamine : 5-20mcg/kg/min iv , starting at 5mcg/kg/min and increasing by 5mcg/kg/min (dosage of >20mcg/kg/min may result in vasoconstriction or arrhythmia)

isoproterenol : 20-60mcg iv bolus followed doses of 10-20mcg or infusion of 1-20mcg/min based on heart rate response (monitor for potential development of ischemic chest pain)

epinephrine : 2-10mcg/min iv or 0.1-0.5mcg/kg/min iv titrated to desired effect 


in case of second or third atrioventricular block associated with acute inferior MI : 

aminophylline 250mg iv bolus 

in case of calcium channel blocker overdose :

10%calcium chloride 1-2g iv every 10-20min or an infusion of 0.2-0.4ml/kg/hr

10% calcium gluconate 3-6g iv every 10-20min or infusion at 0.6-1.2ml/kg/hr

in case of beta-blocker or calcium channel blocker overdose :

glucagon 3-10mg iv with infusion of 3-5mg/h 

high dose insulin therapy iv bolus of 1unit/kg followed by an infusion of 0.5unit/kg/h(follow glucose and potassium levels)

in case of digoxin toxicity :

digoxin antibody fragment dosage dependent on amount ingested or known digoxin concentration (one vial binds approximately 0.5mg of digoxin , administer over at least 30min , may be repeated )

in case of post heart transplant :

aminophylline 6mg/kg in 100-200ml of iv fluid over 20-30min

theophylline 300mg iv , followed by oral dose of 5-10mg/kg/d titrated to effect (therapeutic serum levels range from 10-20mcg/ml) usual posttransplant dosage average 450mg+-100mg/d

in case of spinal cord injury :

aminophylline : 6mg/kg in 100-200ml of iv fluid over 20-30min 

theophylline oral dose of 5-10mg/kg/d titrated to effect (effective dosage often result in serum level below usual effective range 10-20mcg/ml)

































Comments